Case gallery
From biological sample to interpretable density.
Each case follows the biological question, the reconstruction evidence, and the final map quality — the way a structural biology team reads a result.
01 — End-to-end workflow
From raw movies
to a solved atomic structure.
Ariadne decomposes the cryo-EM pipeline into three evidence-gated stages. Each stage has to prove itself before the next begins — so a downstream step never builds on an unsupported upstream decision.
“Route by evidence.”Particle curationstage 01
Motion, CTF, picking & cleaning — until a trustworthy particle set exists.
evidence gate
Volume reconstructionstage 02
Ab-initio, heterogeneity & refinement — until the density is real and resolved.
evidence gate
Model buildingstage 03
Model building & validation — an interpretable structure you can publish.
02 — Professional tool mastery
One agent,
every leading tool.
Rather than lock to a single package, Ariadne picks the most suitable specialist for each stage among best-in-class cryo-EM software — and orchestrates them into one coherent scientific strategy.
CryoSPARC
3D reconstruction & refinement
RELION
Reconstruction & refinement
CryoSMART
Cloud Cryo-EM Data Processing Platform
DRACO
Micrograph denoising & particle picking
CryoUNI
Structural landscape determination
CryoACE
Atomic model building
More on the way
Additional structural biology tools and execution engines
03 — Knowledge base
Grounded in cryo-EM
knowledge — and yours.
Ariadne stands on a curated cryo-EM knowledge base distilled from the literature and hard-won practice. And it personalizes: feed it your own papers and past workflows, and it reconstructs the way your team would.
Curated knowledge
Best practices, failure modes and decision heuristics distilled from cryo-EM literature and real reconstructions.
Your lab, internalized
Point Ariadne at your papers and prior projects; it learns your conventions and replays your team's strategy.
Result Gallery
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Early access
Push the frontier of structuralbiology with Ariadne.
We're onboarding a select group of university labs and research groups through an application-based early-access program. If you're pushing the frontier of structural biology, we'd like to hear from you.